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Observe Intently (two)pentobarbital will reduce the extent or effect of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Solid CYP3A4 inducers may reduce suvorexant efficacy; if elevated suvorexant dose demanded, don't exceed twenty mg/working daypentobarbital will minimize the level or influence of theophylli